The invention relates to a topical therapeutic system which comprises: a backing layer; an active ingredient-containing matrix layer which contains at least one active ingredient, at least one permeation enhancer, at least one non-occlusive adhesive, at least one antioxidant and at least one crosslinking agent; and an occlusion-producing layer that contains at least one adhesive and that is located between the active ingredient-containing matrix layer and the backing layer.