MANUFACTURING METHOD OF ULTRA-HIGH MOLECULAR WEIGHT POLY GLYCOL ACID HAVING BIODEGRADABLE AND IMPLANT HAVING HIGH STIFFNESS AND BIODEGRADABLE MANUFACTURING THEREOF
JEON, SEUNG HO,전승호,PARK, JONG,박종,LEE, JONG SEONG,이종성,SONG, JEE YOUNG,송재영,LEE, JIN KWON,이진권,JEON, SEUNG HOKR,PARK, JONGKR,LEE, JONG SEONGKR,SONG, JEE YOUNGKR,LEE, JIN KWONKR
申请号：
KR1020150033730
公开号：
KR1015681460000B1
申请日:
2015.03.11
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a method for producing biodegradable polyglycolic acid with an ultra-high molecular weight and a high-stiffness, and biodegradable implant including the biodegradable polyglycolic acid with an ultra-high molecular weight produced by the same. The method includes the following steps: a) obtaining pellets (A) of polyglycolic acid with a weight average molecular weight of 10,000-50,000 by inserting glycolide, a reaction initiation catalyst, and a catalyst in an reactor and performing ring-opening polymerization； b) obtaining pellets (B) of polyglycolic acid with a weight average molecular weight of 100,000-1,000,000 by inserting the pellets (A) of polyglycolic acid and glycolide in a reaction extruder and performing ring-opening polymerization and chain polymerization and condensation reaction； and c) obtaining pellets (C) of polyglycolic acid with a weight average molecular weight of 1,000,000-10,000,000 by performing solid-phase polymerization on the pellets (B) of polyglycolic acid in a condition of the temperature from a glass transition temperature or higher to a melting temperature of polyglycolic acid or lower, in a vacuum condition, or under an inert gas atmosphere.본 발명은 a) 글리콜리드, 반응개시촉매 및 촉매를 반응기에 투입하고 개환중합반응을 진행하여 중량평균분자량 10,000 내지 50,000의 폴리글리콜산 펠렛(A)를 얻는 단계； b) 상기 폴리글리콜산 펠렛(A)에 글리콜리드를 반응압출기에 투입하고 개환중합 및 사슬중축합반응을 진행하여 중량평균분자량 100,000 내지 1,000,000의 폴리글리콜산 펠렛(B)를 얻는 단계； 및 c) 상기 폴리글리콜산 펠렛(B)를 폴리글리콜산의 유리전이온도 이상 용융온도 이하의 온도 조건, 진공 또는 불활성기체 분위기 하에서 고상중합을 진행하여 중량평균분자량 1,000,000 내지 10,000,000 범위의 폴리글리콜산 펠렛(C)를 얻는 단계；를 포함하는 초고분자량 생분해성 폴리글리콜산의 제조방법 및 이로부터 제조된 초고분자량 생분해성 폴리글리콜산을 포함하는 고강성 생분해성 임플란트에 관한 것이다.
