MARK L. TYKOCINSKI;MICHAL DRANITZKI ELHALEL;YOSI GOZLAN;NOAM SHANI;KAHR Medical Ltd.;Edwin BREMER;Ido KAMINSKY
发明人:
MARK L. TYKOCINSKI,MICHAL DRANITZKI ELHALEL,YOSI GOZLAN,NOAM SHANI,Edwin BREMER,Ido KAMINSKY
申请号：
IL26786119
公开号：
IL267861D0
申请日:
2019.07.04
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
PD1-41BBL fusion proteins are provided. Accordingly, there is provided a PD1-41BBL fusion protein comprising a single amino acid linker between the PD1 and the 41BBL. Also there is provided a PD1-41BBL fusion protein, wherein the PD1 amino acid is 123-166 amino acids in length and/or wherein the PD1 amino acid sequence comprises SEQ ID NO: 2 and/or wherein the fusion protein is in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the PD1-41BBL fusion protein, host-cells expressing the PD1-41BBL fusion protein and methods of use thereof.
