Use of tetrahydrocannabivarin (THCV) either on its own or further comprising cannabidiol (CBD)_in the treatment of epilepsy and more particularly to the treatment of generalized seizures. One embodiment relates to the use of the cannabinoid THCV as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In a further embodiment, the THCV or THCV containing extract is mixed with CBD or a CBD rich extract to benefit from the anti-epileptic activity of the CBD.