Systems, methods, and computer-readable storage media relate to generate an integrated image based on strain data and elastic model. The method may include determining, by a processor, a range of probe positions for placement of an ultrasound probe with respect to a patient based on strain data, the range of positions including a first position, a second position, and one or more positions there between. The method may also include acquiring 3D TRUS images of the patient at each of the one or more positions of the range and generating a patient specific biomechanical model based on the 3D TRUS images. The method may further include integrating the patient specific biomechanical model, the 3D TRUS images and MR images to generate an integrated image of the prostate. The methods, systems, and computer readable media can improve efficiency and accuracy of 3D TRUS and MR image registration, e.g., for image-guided interventions.
