The present invention relates to the biomedical sector and, more specifically, to the processes of disinfection, and preferably of sterilization, of medical instruments. In detail the invention relates to a case (1) for the sterilization and conservation of thermolabile endoscopes adapted to be used, in cooperation with an automatic machine, in a process of washing and sterilizing one of said endoscopes comprising a plurality of channels, where said case (1) comprises: - a first shell ( 10) and a second shell (20); - reversible fastening means between said first (10) and second (20) shell; - a plurality of connectors (2) lor the channels of said endoscope, adapted to allow ihe injection of process liquids and/or gas into said channels; - an inlet connector (3) and an outlet connector (4), adapted to allow the injection and discharge of process liquids and/or gas into and out of said case (1); - a handle (5) and supporting feet. Said first (10) and said second (20) shell reproduce in the plan view a shape with a substantially circular overlapping edge, and the surface of said first (10) and said second (20) shell comprises a convex portion (10a, 20a) placed In the proximity of said edge and a concave portion (10b, 20b) in the central zone, where said portions (10a, 10b, 20a, 20b) are connected to one another With a curved profile, free of corners.La présente invention concerne le secteur biomédical et, plus spécifiquement, les procédés de désinfection, et de préférence de stérilisation, d'instruments médicaux. En détail, l'invention concerne une boîte (1) pour la stérilisation et la conservation d'endoscopes thermolabiles conçue pour être utilisée, en coopération avec une machine automatique, dans un procédé de lavage et de stérilisation d'un desdits endoscopes comprenant une pluralité de canaux, ladite boîte (1) comprenant : - une première coque (10) et une seconde coque (20) ; - des moyens de fixation réversibles entre lesdites première (10) et seconde (20) coque ;