The application discloses circRNAs as new biomarkers for the diagnosis of heart failure, the prediction of the clinical evolution of heart failure and/or prediction of the response to a treatment in a patient； methods for the prediction of outcome and diagnosis of heart failure and/or predicting the response to a treatment are provided based on measuring said one or more circRNAs； and kits and devices for measuring said circRNAs and/or performing said methods. Further provided are methods for treating patients with heart failure based on the evaluation of said one or more circRNAs.
