Allison Y. Luo,Wendy L. Trigona,Jinshan Shen,Li-An Xu,Yan Zhang,Bruce Stouffer,Haibin Chen,Haichun Huang,Xiaolu Tao,Catherine Brockus
申请号：
US14055238
公开号：
US09429581B2
申请日:
2013.10.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In certain embodiments, the present invention provides a method of treating an Interferon gamma inducible protein 10 (IP-10)-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IP-10 antibody； (b) detecting the level of the anti-IP-10 antibody in a sample of the subject； and (c) if the level of the anti-IP-10 antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IP-10 antibody in the subject such that the IP-10 related disease in the subject is treated. In certain embodiments, the present invention provides an isolated monoclonal anti-idiotypic antibody, or an antigen binding portion thereof, which binds to the anti-IP-10 antibody MDX-1100.
