The present invention relates to an ultrasonic syringe and method of use for delivery and withdrawal of fluids from a human and/or animal patient. The ultrasonic syringe apparatus comprises a generator, a movable ultrasound transducer, a barrel, an ultrasound transducer tip, a radiation surface, an orifice located at the front end of the barrel, and a syringe head. The apparatus may further comprise a channel, a valve located on the distal end of the channel, and an orifice within the side wall which enables fluids to be delivered into the barrel. Ultrasonic waves emitting from the radiation surface induce vibrations within the fluids, sonicating the fluids, thereby eliminating the pain and discomfort associated with receiving injections, reducing and/or eliminating the force required to administer the injection, decreasing delivery time of the fluids into the body, and delivering ultrasonic energy to the tissue via the sonicated fluids.
