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Conjugation of peptides by transglutaminase
专利权人:
Novo Nordisk Health Care AG
发明人:
Johansen, Nils Langeland,Zundel, Magali,Dörwald, Florencio Zaragoza
申请号:
ES14191805
公开号:
ES2642214T3
申请日:
2005.01.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminiated peptide with e.g. a functionalised polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.
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