亿京国际有限公司;億京國際有限公司;BILLION KING INTERNATIONAL LIMITED
发明人:
WONG, Bing Lou,黄炳鏐,黃炳鏐,KWOK, Sui Yi,郭瑞仪,郭瑞儀
申请号：
MOJ002064
公开号：
MOJ002064B
申请日:
2016.02.26
申请国别(地区):
MO
年份:
2016
代理人:
摘要：
The present invention provides the non-polymeric tetrameric hemoglobins of a kind of highly purified and heat-staple crosslinking, are suitble to what mammal without leading to injury of kidney and vessel retraction. High temperature and short time (HTST) thermal work steps are carried out to be effectively removed the hemoglobin, uncrosslinked tetrameric hemoglobin and plasma protein impurity of undesirable dimeric forms. It optionally adds in heat treatment Hou and before heat treatment N-acetylcystein and maintains low-level ferrihemoglobin. The oxygen that the heat-staple cross-linked tetrameric hemoglobin can improve and extend in normal and hypoxemia tissue closes. On the other hand, which treats a plurality of types of cancer such as leukaemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and the cancer of the esophagus with what. Tetrameric hemoglobin of the invention can also be used to prevent the metastases and recurrence of ocal resection Hou. In addition, tetrameric hemoglobin of the invention can apply what patient before chemotherapy and radiation.本發明提供了一種高度純化和熱穩定的交聯非聚合四聚體血紅蛋白，其適合用於哺乳動物而不導致腎損傷和血管收縮。進行高溫和短時間(HTST)熱加工步驟以有效地去除不合乎需要的二聚體形式的血紅蛋白、未交聯的四聚體血紅蛋白和血漿蛋白雜質。在熱處理後和任選地在熱處理前添加N-乙酰半胱氨酸保持了低水平的高鐵血紅蛋白。該熱穩定的交聯四聚體血紅蛋白可以改善和延長正常和低氧組織中的氧合。在另一方面，該産品用於治療多種類型的癌症諸如白血病、結直腸癌、肺癌、乳腺癌、肝癌、鼻咽癌和食管癌。本發明的四聚體血紅蛋白還可以用來預防手術切除腫瘤後的腫瘤轉移和復發。此外，本發明的四聚體血紅蛋白可以在化療和放療之前施用於患者。
