Chichi Huang,Michael G. Sheppard,Xuemei Cao,Gabriele M. Zybarth
申请号：
US13165877
公开号：
US20120021001A1
申请日:
2011.06.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
