PHARMACEUTICAL COMPOSITION FOR INHIBITING THE TRANSCRIPTION FACTOR INDUCIBLE BY HYPOXIA, MODULATORS OF PATHOLOGICAL PROCESSES OF ANGIOGENESIS, ONCOGENESIS, INFLAMMATION, APOPTOSIS, AND CELLULAR THERAPY
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE
发明人:
GARIJO OLMO, RAQUEL,CHIVA TARREGA,ACENA BONILLA, JOSE LUIS,RODRIGUEZ JIMENEZ, FRANCISCO JAVIER,FARRAS RIVERA, ROSA,LUCAS DOMINGUEZ, RUT,MULLOR SANJOSE, JOSE LUIS,SANZ-CERVERA, JUAN, FRANCISCO,MORENO M
申请号：
EP09720498
公开号：
EP2292587A4
申请日:
2009.03.11
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention is included in the field of pharmacology and medical chemistry and relates to novel molecules represented by general formula (I), especially the one called FM19G11, as well as to pharmaceutical compositions containing them. Said pharmacologically optimized compositions are capable of modulating and/or inhibiting the transcription of genes modulated by the hypoxia-inducible transcription factor (HIF) and which are directly and/or indirectly involved in pathological processes related to cancer, inflammation, tissue repair, stem cell differentiation and regenerative therapy.The present invention also relates to a method for the synthesis of said molecules (I) and to the use thereof in the manufacture of a medicament for the treatment of the mentioned pathological processes.
