CURIEL, DAVID T.,KRASNYKH, VICTOR N.,ALEMANY, RAMON,DMITRIEV, IGOR
申请号：
AT00932375
公开号：
AT540686T
申请日:
2000.05.12
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
A modified adenovirus capable of overcoming the problem of low level of coxsackle-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to mutations in E1a or E1b genes.
