KC, SUNIL KUMAR,MAK, CHI CHING,EASTMAN, BRIAN WALTER,CAO, JIANGUO,BOLLU, VENKATAIAH,MITTAPALLI, GOPI KUMAR,CHIRUTA, CHANDRAMOULI
申请号：
CA3022002
公开号：
CA3022002A1
申请日:
2017.04.27
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
