The several helminths for being responsible for mammalian diseases depend on the various life cycle functions of cysteine proteinase. The inhibition of specific cysteine protease or reduce function can be used for treating and/or prevent these parasitic diseases, including trichomoniasis, tissue inflammation, globidiosis, trypanosomiasis and Cryptosporidiosis. The compound of formula I can treat with/or prevention mammal in above-mentioned disease, such as in the birds of the galliformes birds such as chicken, turkey, duck, goose, capercaillie, Guinea chicken, peacock, quail, Zhe nautilus and pheasant, Falconiformes, pertussis, colon. Hook-type mesh Columbuss Livia housefly), Psittacidae and domestic mammals, such as ox, sheep, goat, horse, pig, camel, lama, alpaca, cat and dog.
