A method of treatment of sinusitis and other related diseases including disposing a radially expandable stent into a nasal passageway and radially expanding the stent in a blocked region of the nasal passageway to expand the blocked region is disclosed. The stent includes a tissue-cushioning portion composed of a hydrogel-forming or elastomeric polymer material to provide cushioning between the stent and nasal tissue and reduce irritation of the nasal tissue.