PROBLEM TO BE SOLVED: To provide a percutaneously absorbable medicated patch with suppressed change in pressure-sensitive adhesive characteristics with time and excellent sustained medicament release.SOLUTION: The percutaneously absorbable medicated patch 1 includes a substrate 11, a medicament storage layer 12 formed on either side of the substrate 11 and containing a medicament, a first pressure-sensitive adhesive layer 13 formed between the substrate 11 and the medicament storage layer 12 and adhering the substrate 11 to the medicament storage layer 12, a second pressure-sensitive adhesive layer 14 formed on the surface of that side of the medicament storage layer 12 which is opposite to the substrate 11, and a release sheet 15 formed on that surface of the second pressure-sensitive adhesive sheet 14 which is stuck to the skin, wherein the gel fraction of the first pressure-sensitive adhesive layer 13 is 45-95%, the gel fraction of the second pressure-sensitive adhesive layer 14 is 55-95%, and the relationship: T2/T1&ge2 holds: wherein T1 [&mum] is the average thickness of the first pressure-sensitive adhesive layer 13, and T2 [&mum] is the average thickness of the second pressure-sensitive adhesive layer 14.COPYRIGHT: (C)2010,JPO&INPIT【課題】経時的な粘着特性の変化を抑制することができるとともに、薬物の持続的な徐放性に優れた経皮吸収貼付剤を提供すること。【解決手段】経皮吸収貼付剤1は、支持基材11と、支持基材11の一方の面側に設けられ、薬物を含有する薬物貯蔵層12と、支持基材11と薬物貯蔵層12との間に設けられ、支持基材11と薬物貯蔵層12とを接着する第1の粘着層13と、薬物貯蔵層12の支持基材11とは反対側の面に設けられた第2の粘着剤層14と、第2の粘着剤層14の皮膚に貼着する側の面に設けられた剥離シート15を有している。また、第1の粘着剤層13のゲル分率が45~95%であり、第2の粘着剤層14のゲル分率が55~95%であるとともに、第1の粘着剤層13の平均厚さをT1[μm]、第2の粘着剤層14の平均厚さをT2[μm]としたとき、T2/T1≧2の関係を満足する。【選択図】図1
