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Benzoxazepine derivatives and use thereof
专利权人:
Junya Shirai;Takahiro Matsumoto;Izumi Kamo
发明人:
Junya Shirai,Takahiro Matsumoto,Izumi Kamo
申请号:
US12449975
公开号:
US08247403B2
申请日:
2008.03.06
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compounds represented by the general formula (I):wherein each symbol is as defined in the description [with the proviso that 9-chloro-7-(1,1-dimethylethyl)-2,3,4,5-tetrahydro-1,4-benz-oxazepine and N-[[(5S)-2-oxo-3-(2,3,4,5-tetrahydro-1,4-benz-oxazepin-7-yl)-5-oxazolidinyl]methyl]acetamide are excluded], salts of the same, and prodrugs thereof have selective activation effect on serotonin 5-HT2C receptor and are useful as preventive and therapeutic agents for lower urinary tract diseases, obesity, and/or pelvic organ prolapse.
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