A hydrophilic medium-soluble composition comprising . (A) hydrophobic physiologically active ingredient (preferably, Minoxidil) (B) silicone compound having specific hydrophilic group (preferably polyether group) and (C) silane having specific hydrophobe group (preferably polyether group). Insoluble hydrophobic physiologically active ingredient are stabilized by a combination of said component (B) and (C) in the hydrophilic medium selected from water, alcohols and a mixture thereof without crystallization. The obtained clear hydrophilic medium-soluble composition is useful as a cosmetic raw material or quasi-drag raw material.
