The present invention provides a catheter clamp assembly having a base and a slide cover. The base has a top, bottom and a body including a slide cover track. The body has internal walls defining a catheter opening extending from the bottom to the top. A catheter channel extends from the catheter opening to a sidewall opening. The slide cover includes a lower surface incorporating a prong to engage a wall defining the catheter opening and to secure a catheter in the catheter channel. The slide cover has a first location providing access to the catheter opening and a second location that clamps a catheter in the catheter channel. Moving the slide cover from its first location contacts a length of catheter extending through the catheter opening to position it in the catheter channel for securement when the slide cover reaches its second location.