A hard shell capsule includes a body and a cap cooperatively defining a hollow core hard shell capsule. Each of the body and the cap has a composition that includes a polymer forming a hard polymer structure of the body and of the cap, at least one of the body and the cap composition including a therapeutically effective amount of a drug(s) used in the treatment of irritable bowel syndrome loaded throughout the body and/or cap. The second drug(s) may be filled in the capsule core.
