Compositions comprising aortic material and methods for using harvested blood vessels (e.g. arteries or veins e.g. aortae) graft procedures e.g. for restoring and repairing luminal structures (e.g. in the aerodigestive tract such as the larynx pharynx and esophagus) as tissue fillers (e.g. injectable morselized blood vessel tissues for use in cosmetic applications and functional sphincter enhancement) and as biological structural supports (e.g. intact portions of aortae for use in repairing abdominal wounds anastomoses bony repairs and the heart).