A system and method for processing breast tissue images. The system comprises an image processing computer and a user interface operatively coupled to the image processing computer. The image processing computer is configured to obtain tomosynthesis image data of breast tissue, and process the tomosynthesis image data to generate a set of reconstructed image slices and/or a set of image slabs, each image slab comprising a synthetic image of a portion of the breast tissue obtained from a respective subset of the set of reconstructed image slices. The image processing computer is configured to generate each image slab of the set of image slabs from a predetermined number of successive reconstructed image slices, wherein adjacent image slabs of the set include a predetermined or a user inputted overlap number of successive reconstructed image slices.
