This invention, the inhibiter of sonic hedgehog path, especially, is the Smo antagonist, the chemical compound of formula I or it regards the salt or tautomerization isomer which that pharmacy is allowed. Therefore, as for the constituent of this invention, for example, it is useful for the remedy of the disease which the basal cell cancer, the medulla blastoma, the prostate cancer and the pancreas cancer, includes the cancer of the breast cancer, colon cancer, the bone cancer and the small cell lung cancer and the upper alimentary canal, is related with abnormal hedgehog path activation.本発明は、ソニックヘッジホッグ経路の阻害剤、特に、Smoアンタゴニストである、式Iの化合物又はその薬学的に許容される塩又は互変異性体に関する。したがって、本発明の組成物は、例えば、基底細胞癌、髄芽細胞腫、前立腺癌、膵臓癌、乳癌、結腸癌、骨癌及び小細胞肺癌並びに上部消化管の癌を含む、異常なヘッジホッグ経路活性化と関連している疾患の治療にとって有用である。
