Ligands that bind to the complex of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) that inhibit downstream uPAR interactions: identification and use in diagnosis or therapy

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专利权人:

アテニュオン，;エルエルシー;アテニュオン, エルエルシー

发明人:

ペリー， グラハム シー．,ペリー, グラハム シー.

申请号：

JP2007515288

公开号：

JP4890449B2

申请日:

2005.05.25

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

Antibodies or other ligands specific for the binary uPA-uPAR complexes, for ternary complexes comprising uPA-uPAR and for complexes of uPAR and proteins other than uPA such as integrins inhibit the interaction of uPA and uPAR with additional molecules with which the complexed interact. Such antibodies or other ligands are used in diagnostic and therapeutic methods, particularly against cancer.

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中国工程科技知识中心

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http://www.ckcest.cn/home/