A chiller is coupled to a plurality of cuffs suitable for application to extremities of a human subject, each cuff having an outer support belt with an adjustable diameter and an inner bladder having an inlet port and an outlet port. The bladder has one surface constrained by the support belt and an opposite surface for application of pressure and cooling to an enclosed human extremity. The plurality of cuffs are connected to the cooler with a series of outlet ports and inlet ports such that the chiller causes the cuffs to be pressurized with a coolant which provides vascular restriction and cooling to increase the formation of human growth hormone.
