KATARINA LINDELL,FREDRIK NICKLASSON,KRISTINA THYRESSON,FRANK BUNICK,JOE LUBER,ANDREAS HUGERTH
申请号：
PT09820843
公开号：
PT2361081T
申请日:
2009.10.13
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers/signals as conceptual aids for the subject.,Also contemplated are a method and a system for delivering active agents, such as,nicotine and/or metabolites thereof, such as cotinine, nicotine N'-oxide, nornicotine, (S)-nicotine-N-ß-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.
