PROBLEM TO BE SOLVED: To manufacture a candesartan cilexetil-containing preparation by a simple method in terms of preparation operation, which guarantees quality for a long period of time even when stored in a distribution process or in an unpacked state.SOLUTION: The candesartan cilexetil-containing solid preparation that has improves reduction in content with time by pressure, friction, etc., and has superior storage stability and strength to stand distribution state on the market is provided by manufacturing tablets by tableting pressure in a range of 0.2-2 kN in a tableting process of the candesartan cilexetil-containing tablet.COPYRIGHT: (C)2012,JPO&INPIT【課題】カンデサルタンシレキセチル含有製剤を製剤操作上簡便な方法で製造し、流通過程や無包装状態で保管した場合にも長期間品質が保証できる製剤を提供する。【解決手段】カンデサルタンシレキセチル含有錠の打錠工程において、打錠圧力を0.2~2kNの範囲で錠剤を製造することにより、圧力、摩擦等による経時的な含量低下を改善し、保存安定性に優れ、かつ、市場での流通状態に耐えうる強度を有するカンデサルタンシレキセチル含有固形製剤を提供する。【選択図】なし。
