A disposable flexible multi panel sterilization assembly incorporating an integrated fastening system. The disposable flexible multi panel sterilization assembly includes a barrier panel formed from a sheet of barrier material having at least one panel edge. The barrier panel is configured to be folded around content to be sterilized to form a package. The assembly further includes a fold protection panel extending from the barrier panel. The fold protection panel includes a proximal end generally adjacent the barrier panel and a distal end generally opposite the proximal end such that the distal end of the fold protection panel covers the one or more panel edges of the barrier panel after the barrier panel is in the folded configuration. The integrated fastening system is barrier panel attachment means located on a portion of the barrier panel for securing one or more panel edges of the barrier panel in a folded configuration around content to be sterilized. The barrier panel attachment means are configured to secure the one or more panel edges in a folded configuration.
