PROBLEM TO BE SOLVED: To provide a skin associated enzyme activator which promotes enzyme activity associated with the skin condition, and improves skin condition.SOLUTION: The invention provides an external preparation for skin consisting of a yeast extract, which contains a heat shock protein and/or a heat shock factor.COPYRIGHT: (C)2015,JPO&INPIT【課題】肌状態に関連する酵素活性を向上させ、肌状態を改善する皮膚関連酵素活性化剤の提供。【解決手段】酵母抽出物からなる皮膚外用剤で、該酵母抽出物がヒートショックプロテイン及び/又はヒートショック因子を含有する皮膚外用剤。【選択図】図1