Referring to a Derivative of exendin-4 Peptide Compound with the formula (i): R1 - R2 Z, where z is a remainder of formula (ii): Peptide Tyr Gly THR AIB - X3 - Phe - Thr ser ASP Leu GLN be X12 x14 x15 x16 Concept - - - - - - X18 x19 X20 X21 - Phe Ile Glu Lys TRP - Leu - X28 X29 Gly - Pro - be Gly ala pro Pro Pro ser - X 40 r1 is NH2 Group R2 is the c-terminal Peptide compound and select of Oh and NH2.These compounds are agonists of the receptor peptide glp-1 and GIP being useful in the treatment of disorders such as obesity, Diabetes and metabolic syndromeREFERIDA A UN COMPUESTO PEPTIDICO DERIVADO DE EXENDINA-4 QUE TIENE LA FORMULA (I): R1-Z-R2, EN DONDE Z ES UN RESTO DE PEPTIDO DE FORMULA (II): Tyr-Aib-X3-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-X12-Gln-X14-X15-X16-X17-X18-X19-X20-X21-Phe-Ile-Glu-Trp-Leu-Lys-X28-X29-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X40 R1 ES NH2 R2 ES EL GRUPO C-TERMINAL DEL COMPUESTO PEPTIDICO Y SE SELECCIONA DE OH Y NH2. DICHOS COMPUESTOS PEPTIDICOS SON AGONISTAS DEL RECEPTOR GLP-1 Y GIP SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SINDROME METABOLICO TALES COMO DIABETES Y OBESIDAD
