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Pyridonaphthyridine PI3K/MTOR Dual Inhibitors and Preparation and Use Thereof
专利权人:
Yan Zhang;Frank Wu
发明人:
Frank Wu,Yan Zhang
申请号:
US14123934
公开号:
US20140093505A1
申请日:
2012.06.04
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.
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