Interferon alpha2b variants

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专利权人:

Teva Pharmaceuticals Australia Pty Ltd.

发明人:

Behrens, Collette,Doyle, Anthony,Clarke, Adam,Pollard, Matthew,Domagala, Teresa

申请号：

AU20150337858

公开号：

AU2015337858(A1)

申请日:

2015.10.23

申请国别(地区):

澳大利亚

年份:

2017

代理人:

摘要：

The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon α 2b (IFNα2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFNα2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFNα2b.

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