Alexander Richard Liam Cecil;Franck Alexandre Silva;Cyrille Davy Tomassi;Thomas James Hill;Stephen Joseph Shuttleworth
发明人:
Stephen Joseph Shuttleworth,Franck Alexandre Silva,Cyrille Davy Tomassi,Alexander Richard Liam Cecil,Thomas James Hill
申请号：
US12991491
公开号：
US08614193B2
申请日:
2009.05.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The subject application pertains to a compound of structure IX or X:or a pharmaceutically acceptable salt thereof,wherein:X is —C(═O)N(R10)— or —CH(OPr3) —；R7, R9 and R10 are the same or different and represent hydrogen or an amino acid side chain moiety from either a natural or an unnatural amino acid；Pr1 and Pr2 are the same or different and represent hydrogen or a thiol protecting group；Pr3 is hydrogen or an alcohol protecting group；R1, R2, R5 and R6 are the same or different and represent hydrogen or an amino acid side chain moiety from either a natural or an unnatural amino acid, or R1 and R2 and/or R5 and R6, taken together with the carbon atom to which they are attached, form a spirocyclic moiety,with the proviso that:each of R1 and R2 is not hydrogen, oreach of R5 and R6 is not hydrogen.
