The invention relates to pharmacology and can be used for treating liver diseases of various etiologies, inter alia, in combination with other preparations. Claimed is a drug with hepatoprotective activity comprised of 3-(4-bromophenyl)-6,6-dihydroxy-5-hydroxyiminohexahydro-2,4-pyrimidinedione and salts thereof of general formula (I),where X is selected from the group: H, Na, K, or from the group of hydroxyalkylammonia derivatives of general formula (II),where R1, R2 are selected from the group: H, CH3, CH2CH3, CH2CH2OHR3 is selected from the group: H, H2OH and n = 1,2the drug can be prepared in the form of tablets or capsules for enteral administration or in the form of a liquid or lyophilized substance for parenteral administration or in the form of rectal suppositories or in the form of capsules or tablets, or sweets for sucking and may additionally contain the hepatoprotector Heptral or the hepatoprotector Essentiale or the hepatoprotector ursodeoxycholic acid. This increases the effectiveness of a drug with hepatoprotective activity.