PROBLEM TO BE SOLVED: To provide a medical device material in which a calcium phosphate film having high biocompatibility is fabricated in an intended specific site by high adhesion force while excellent mechanical characteristics of tetragonal zirconia are maintained, and a method for manufacturing the material.SOLUTION: A method of manufacturing a medical device material in which a specific site of a medical device material containing tetragonal zirconia is coated by calcium phosphate comprises: a first process of irradiating a specific site with ultrashort pulse laser to form irregularities on a surface and a second process of evaporating or precipitating calcium phosphate fine particles having a smaller size comparing to the size of irregularities on the specific site. Furthermore, the method may also include a third process of allowing the medical device material containing tetragonal zirconia to contact supersaturated calcium phosphate solution after the second process.SELECTED DRAWING: Figure 6COPYRIGHT: (C)2017,JPO&INPIT【課題】正方晶ジルコニアの優れた機械的特性を保ったまま、生体親和性の高いリン酸カルシウム膜を、高い密着力で意図した特定部位に作製してなる医療機器材料及びその製造方法を提供する。【解決手段】正方晶ジルコニアを含有する医療機器材料の特定部位にリン酸カルシウムでコーティングする、医療機器材料の製造方法であって、特定部位に超短パルスレーザーを照射して表面に凹凸を形成する第一工程と、特定部位に、凹凸のサイズに比べて小さいリン酸カルシウム微粒子を蒸着または析出させる第二工程とを含む。さらに、第二工程後に、正方晶ジルコニアを含有する医療機器材料を、リン酸カルシウム過飽和溶液に接触させる第三工程を含んでも良い。【選択図】図6
