Systems and methods are disclosed for image reconstruction and enhancement, using a computer system. One method includes acquiring a plurality of images associated with a target anatomy； determining, using a processor, one or more associations between subdivisions of localized anatomy of the target anatomy identified from the plurality of images, and local image regions identified from the plurality of images； performing an initial image reconstruction based on image acquisition information of the target anatomy； and updating the initial image reconstruction or generating a new image reconstruction based on the image acquisition information and the one or more determined associations.
