SHEPARD, HAROLD MICHAEL,THOMPSON, CURTIS,LI, XIAOMING,FROST, GREGORY IAN
申请号：
CA2806058
公开号：
CA2806058A1
申请日:
2011.07.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
