DANIEL RODRIGUEZ GREVE,JENS BJORN JENSEN,KEVIN NEIL DACK,SIMON FELDBAEK NIELSEN,SOREN CHRISTIAN SCHOU
申请号：
BR112013017184
公开号：
BR112013017184A2
申请日:
2012.01.06
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to compounds of general Formula (I), Wherein R1, R2, R3, R4, R5, m, n are defined herein, and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates thereof, for use&mdash；alone or in combination with one or more other pharmaceutically active compounds&mdash；in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immunosuppression would be desirable for example in organ transplantation.
