WHITE, STEVEN K.,STICKNEY, DWIGHT,OLSON, ERIN,LORIMER, KEITH R.,WOLFE, BRENTON S.
申请号：
CA2712005
公开号：
CA2712005C
申请日:
2009.02.05
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides and describes solid state 17.alpha.-ethynyl-5.alpha.-androstane-3.alpha.,17.beta.-diol including amorphous andcrystalline forms and specific polymorphic forms thereof. Anhydrates andsolvates of 17.alpha.-ethynyl-5.alpha.-androstane-3.alpha.,17.beta.-diolincludeForm III anhydrate and Form I solvate. The invention further relates to solidand suspension formulations containing 17.alpha.--ethynyl-5.alpha.-androstane-3.alpha.,17.beta.-diol in a described solid state formand use of the formulations to treat cancers or precancers suchas prostate cancer or breast cancer in subjects or human patients. Theinvention also relates to methods to make liquid formula-tionsfrom solid state forms of 17.alpha.-ethynyl-5.alpha.- androstane-3.alpha.,17.beta.-diol and uses of such formulations in treating the describedconditions.
