Thiazolidine linker for the conjugation of drugs to antibodies

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专利权人:

Philogen S.p.A.

发明人:

Giulio, Casi

申请号：

AU2011307236

公开号：

AU2011307236A1

申请日:

2011.09.16

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

In one aspect, there is provided a protein-drug conjugate compound comprising a protein covalently attached by a linker to one or more drug moieties, wherein the linker has a half-life of from 1 hour to 50 hours in phosphate buffered saline at 37 °C. A carbonyl derivative of LU103793 is also described that can be used in a protein-drug conjugate compound comprising an antibody covalently attached by a linker to the drug moiety comprising, consisting or consisting essentially of the carbonyl derivative.

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