The present invention relates to a DNA-binding molecule which is able to specifically bind to a predetermined nucleotide sequence within the hepatitis B virus genome. The DNA-binding molecule is suitable for use in a method of treating and/or preventing a hepatitis B and/or a hepatitis D virus infection in a patient. The invention also relates to a method for treating and/or preventing a hepatitis B and/or a hepatitis D virus infection in a patient which makes use of the DNA-binding molecule. The invention also relates to vectors, kits and compositions comprising the DNA-binding molecule.