PROBLEM TO BE SOLVED: To provide an endoscopic diagnosis system which can acquire autofluorescence images by which a lesion part can accurately be identified without generating a positional slip among a plurality of the autofluorescence images.SOLUTION: The endoscopic diagnosis system includes a light source LD, a color filter, a photographing element 58, and an image processing section 70. In this case, the light source LD simultaneously emits two excitation rays having different central wave lengths for making the autofluorescence emitted from two autofluorescent substances containing a first autofluorescent substance of which autofluorescence intensity is strong at the lesion part and weak at normal parts, and a second autofluorescent substance of which autofluorescence intensity is strong at the normal parts and weak at the lesion part. The color filter has spectral transmission characteristics which make the autofluorescence emitted from the autofluorescent substances transmit while shielding the excitation rays. The photographing element 58 photographs the autofluorescence which is emitted from each of the first and second autofluorescent substances included in a to-be-observed region and is dispersed by the color filter, and acquires the first and second autofluorescence images when the to-be-observed region of a subject is irradiated with the two excitation rays. The image processing section 70 makes the first and second autofluorescence images displayed on a display apparatus 18 by image-processing the first and second autofluorescence images.COPYRIGHT: (C)2013,JPO&INPIT【課題】複数の自家蛍光画像の間で位置ずれを生じることなく、病変部を正確に識別することができる自家蛍光画像を取得することができる内視鏡診断装置を提供する。【解決手段】自家蛍光強度が病変部で強く正常部で弱い第1の自家蛍光物質と正常部で強く病変部で弱い第2の自家蛍光物質を含む2つの自家蛍光物質から自家蛍光を発光させるための中心波長の異なる2つの励起光を同時に発する光源LDと、励起光を遮光しつつ自家蛍光物質から発せられる自家蛍光を透過する分光透過特性を有するカラーフィルタと、2つの励起光が被検者の被観察領域に照射されることによって、被観察領域に含まれる第1および第2の自家蛍光物質のそれぞれから発せられ、カラーフィルタにより分光される自家蛍光を撮像して第1および第2の自家蛍光画像を取得する撮像素子58と、第1および第2の自家蛍光画像を画像処理して表示装置18に表示させる画像処理部70とを
