AARON R KUNZER,ANDREW JUDD,ANDREW SOUERS,GEORGE DOHERTY,GERARD M SULLIVAN,LE WANG,MICHAEL D WENDT,MILAN BRUNKO,ROBIN FREY,TODD M HANSEN,XIAOHONG SONG,XILU WANG,ZHI-FU TAO
申请号：
BR112014009053
公开号：
BR112014009053A2
申请日:
2012.10.11
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl； Y1 is phenylene or heteroarylene； L1 is a linker； Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl； Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
