Yan, Xiaoqiang,Huang, Zhihua,Yang, Hongzhou,Sun, Bill N.C.,Huang, Yuliang
申请号：
AU2011257734
公开号：
AU2011257734B2
申请日:
2011.05.25
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serum half-life and increased biological activity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexes through the pairing of two Fc fragments via disulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fc fragment of human IgG2, and a peptide connecting the G-CSF monomer and the Fc fragment. The rhG-CSF can be used for the treatment of neurological diseases.
