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Chaperoninas Chemical as a New molecular modulators beta Aggregation of the Protein present in the conformational Diseases
专利权人:
CENTRO DE NEUROCIENCIAS DE CUBA;INSTITUTO MEXICANO DEL SEGURO SOCIAL, IMSS
发明人:
SABLÓN CARRAZANA, MARQUIZA,RODRÍGUEZ-TANTY, CHRYSLAINE,ALTAMIRANO BUSTAMANTE, MYRIAM MARLENE,FERNÁNDEZ GÓMEZ, ISAAC,RIVERA MARRERO, SUCHITIL,VEDRENNE GUTIÉRREZ, FERNAD,RIVILLAS ACEVEDO, LINA ANDREA,LÓ
申请号:
CU20130027
公开号:
CU20130027A7
申请日:
2013.02.28
申请国别(地区):
CU
年份:
2014
代理人:
摘要:
The invention relates to chemistry and biochemistry applied in the field of medicine, and relates to a new method for preventing and treating shaping diseases, in particular by effectively using one or more compounds to prevent and treat amiloriasis. The salt, ore or solution thereof is regarded as the salt of the first equation, wherein: R1: - pitch-c (o) nh-pitch-r4; R3: - COOH -, oh -, SH -, N2 -, pitch-nh -, pitch pitch-pitch-n ndash; dicarboxylic acid alkaline-t metal salt, or the salt of the above-mentioned related groups, can be accepted in medicine,For the treatment of amiroygopathy R4: adsorption group; R2: H, tar. "The term 'tar' refers to a linear crystalline chain or a branch of saturated carbon and water atoms, preferably one to four carbon atoms, including methyl, ethyl, n-propyl, ISO propilo, n-butilo or ISO butilo. The term "tar" refers to various analogues of linear or branched helical liquid groups, preferably Ethiopian (- CH2CH2 -) or butinilo (- ch2ch2ch2ch2ch2 -).lipophilic and low molecular weight compounds of Formula I can be conveniently prepared as described in Cuban Patent No. 2009-57, PCT-CU2010-000001, WO / 2010/118706, EP 2 436 666 A20, and in the Patent applications: Mexico No 29/2011, Brazil: 27/2011, USA 10/2012, Malaysia 12/2012, Japan 9/2012, Canada 7/2012, South Africa 18/12012 The present invention provides a new method of prevention and therapeutic treatment of CD, through the inhibition, reduction, disaggregation of the prefibrillary structures, protofibrils, fibers and amyloid plaques, all characterized by presenting ß-crossed toxic structures (eg Alzheimer's disease (AD),Parkinson's disease (EP)Type 2 diabetes mellitus (DM2), etc,Through the management of formula one compounds, in this invention, it is regarded as any acceptable pharmaceutical component or salt of one or more compounds, whether propha or solvato, which can inhibit, reduce, eliminate, etc, The formation of these structures leads to abnormal protein folding and
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