AST, Oliver,BRUENKER, Peter,FREIMOSER-GRUNDSCHOBER, Anne,HERTER, Sylvia,HOFER, Thomas U.,HOSSE, Ralf,KLEIN, Christian,MOESSNER, Ekkehard,NICOLINI, Valeria G.,UMANA, Pablo
申请号：
AU2015249085
公开号：
AU2015249085A1
申请日:
2015.10.28
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015249085A120151112.pdf#####Abstract The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the a-subunit of the IL-2 receptor, for use as immunotherapeutic 5 agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof 7046133_1 (GHMatters) P93282.AU.1 LEOWNR
