Biaryl derivatives as GPR 120 agonists

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专利权人:

エルジー・ケム・リミテッド

发明人:

キム・ヨングァン,パク・サンユン,チュ・ヒョヌ,チェ・ウンシル

申请号：

JP2016523650

公开号：

JP6322704B2

申请日:

2014.06.26

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The present invention relates to biaryl derivatives of Formula 1, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The biaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in the liver or in muscle due to anti-inflammatory action in macrophages, lipocytes, etc., and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis, osteoporosis or inflammation.

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