脫磷酸化的溶酶體貯積症蛋白及其使用方法

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专利权人:

BIOASISTECHNOLOGIES INC

发明人:

VITALIS, TIMOTHY Z.,GABATHULER, REINHARD

申请号：

HK15111619.1

公开号：

HK1210808A

申请日:

2015.11.25

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having increased ability to traverse or penetrate the blood brain barrier (BBB) relative to phosphorylated forms of the protein, and p97 conjugates thereof. Also provided are compositions comprising such dephosphorylated LSD proteins and p97 conjugates, and methods of use thereof, for instance, to treat any one or more lysosomal storage diseases, such as Hunter Syndrome (or MPS Type II).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/